University of Twente Enhances Cancer-on-a-Chip Technology Research
Enschede, Tuesday, 28 January 2025.
The University of Twente in the Netherlands is advancing cancer-on-a-chip technology to improve cancer diagnostics and treatment, offering a promising alternative to traditional research methods.
Innovative Research at TU Eindhoven
This healthtech innovation is being developed through pioneering research by biomedical engineer Mohammad Jouybar at Eindhoven University of Technology (TUE) [1]. The cancer-on-a-chip technology, which has been in development for approximately fifteen years, represents a significant advancement in disease modeling and therapeutic testing [1]. The research specifically focuses on creating detailed models for studying the metastatic phase of cancer, with particular emphasis on breast cancer ductal carcinoma in situ [1].
Technical Implementation
The microchip model incorporates sophisticated components including breast ducts and blood vessels, constructed using advanced techniques such as femtosecond laser and 3D sugar printing [1]. The chip measures 2-3 centimeters squared, with vessels ranging from 10 to 100 micrometers in diameter [1]. The model for lymphatic vessels is specifically constructed using hydrogel and thin acupuncture needles, incorporating lymphatic cancer cells and fibroblasts [1]. This technical precision allows researchers to study cancer cell movement in unprecedented detail [1].
Benefits and Advantages
The technology offers several significant advantages over traditional research methods. According to Jouybar, it presents a ‘smarter, ethical, and cost-effective alternative to animal testing’ [1]. The system enables researchers to better understand how cancer originates, develops, and moves through the body [1]. This detailed understanding could lead to new drug development and more effective treatments [1]. The research is particularly valuable as it aims to personalize cancer treatment through tailored models for different cancer types [1].
Future Implications
The timing of this research advancement coincides with Health Week (January 28 to February 4, 2025), highlighting its significance in cancer research [1]. The collaboration between TUE and Amsterdam UMC demonstrates the broader academic engagement in this field [1]. As Mohammad Jouybar states, ‘I expect much from how engineering can assist and boost medical research’ [1], suggesting promising developments in the future of cancer treatment and research methodologies [1].